Raina Giusti put Birkirkara ahead on the 10th minute and an own goal put them two goals ahead on the half-hour. One minute later, Gozo pulled one back thanks to Maria Farrugia but a brace by Tracy Teuma on the 61st and 81st secured the points for Birkirkara.
Hibernians had to wait until the final thirty minutes to score three and beat Raiders (Luxol) 3-0 at the Charles Abela Stadium on Tuesday thanks to a goal by Emma Xuereb on the 61st, a Charlene Zammit penalty on the 66th and a Jade Flask goal one minute from time.
On Wednesday, Liis Pello scored the all-important goal for Kirkop United as they defeated Mgarr United 1-0 at the Charles Abela Stadium.
In another match, goals by Francesca Zarb on the 14th, Mariah Micallef on the 48th and Olivia Jimenez Medina on the 58th gave Mosta a 3-0 win over Kirkop United Team B at the Zebbug Ground in another match on Tuesday.