Desira Buttigieg started his career with the Paola Hibernians nursery but joined St. Andrews at the age of sixteen. With the Saints, he made his Premier League debut in 2015/16. Just a few days following his debut, Birkirkara signed him on a five-year contract but as part of the deal, he remained with the Saints on loan for the rest of the season, returning with the Stripes last summer.