Champions Luxol St. Andrews Futsal were drawn in Group A along with hosts Proekt of Northern Macedonia, Dolphins Ashdod of Israel and Cefn Druids of Wales in the preliminary round of the UEFA Futsal Champions League 2021/22.

The competition returns to its regular format for 2021/22 and the season begins with the preliminary round between the 20 and 25 August.

For Proekt and Cefn Druids, this will be their first experience in the competition.

The group winners and best runner-up go through to join the 23 clubs entering in the main round.

Preliminary round groups (20–25 August)

Group A: Luxol St. Andrews Futsal (MLT), Proekt (MKD, hosts), Dolphins Ashdod (ISR), Cefn Druids (WAL)

Group B: Futsal Mineva (SUI, hosts), Dinamo Plus (MDA), Varna City (BUL), Fiorentino (SMR)

Group C: Haladás VSE (HUN), Differdange (LUX), KF Tirana (ALB, hosts), Utleira Idrettslag (NOR)

Group D: JB Futsal Gentofte (DEN), SMS Viimsi (EST, hosts), Hammarby (SWE), Sparta Belfast (NIR)

Group E: KMF FON (SRB), MFC CIU (GEO), Blue Magic FC Dublin (IRL), Titograd (MNE, hosts)

Group F: Araz Naxçivan (AZE), Kampuksen Dynamo (FIN), Raba (LVA, hosts), Europa (GIB)

Group G: APOEL (CYP), Doukas (GRE, hosts), Diamant Linz (AUT), Encamp (AND)

Group H: Weilimdorf (GER, hosts), Liqeni (KOS), London Helvecia (ENG), Tavşançalı (TUR)