The other Gozitan team, Sannat Lions, will be hosting Rabat Ajax.
Balzan and Floriana were paired with two First Division Gzira United and Lija Athletic respectively. Third Division side Marsaskala meet Zebbug Rangers from Division 2. The other clash is between First Division sides St. Andrews and Mqabba.
Fourth Round
1. Balzan vs Gzira United
2. Valletta vs Nadur Youngsters
3. Sannat Lions vs Rabat Ajax
4. Marsaskala vs Zebbug Rangers
5. St. Andrews vs Mqabba
6. Gudja United vs Hibernians
7. Lija Athletic vs Floriana
8. Qormi vs Birkirkara
to be played 18-23 January
Quarter Finals
Winner Match 1 vs Winner Match 8
Winner Match 5 vs Winner Match 7
Winner Match 3 vs Winner Match 2
Winner Match 6 vs Winner Match 4
to be played on 17 February