The Stripes, who suffered back-to-back defeats to Balzan and Hibernians, are currently ninth on 13 points.
On the other hand, St. Andrews share the eleventh place on seven points. They have gone five matches without a win, earning a point in a draw with Lija Athletic last week.
Kurt Zammit and Lucas Maia Verone are ruled out for Birkirkara as they serve a one-match ban.