The Malta Football Association released the fixtures for match day 4 to match day 11 of the BOV Challenge League 2021/22.
Group A
| 15/10/2021 | 21:00 | Centenary Stadium | Lija Athletic | vs | Vittoriosa Stars |
| 16/10/2021 | 19:00 | Centenary Stadium | Marsaxlokk | vs | Zejtun Corinthians |
| 16/10/2021 | 19:00 | Victor Tedesco Stadium | San Gwann | vs | Naxxar Lions |
| 17/10/2021 | 19:00 | Centenary Stadium | Rabat Ajax | vs | Pembroke Athleta |
| 17/10/2021 | 19:00 | Victor Tedesco Stadium | St. George’s | vs | Melita |
| 22/10/2021 | 17:00 | Centenary Stadium | Vittoriosa Stars | vs | San Gwann |
| 22/10/2021 | 21:00 | Victor Tedesco Stadium | Zejtun Corinthians | vs | Naxxar Lions |
| 23/10/2021 | 15:00 | Victor Tedesco Stadium | Mqabba | vs | Rabat Ajax |
| 24/10/2021 | 11:00 | Centenary Stadium | Melita | vs | Lija Athletic |
| 24/10/2021 | 15:00 | Victor Tedesco Stadium | Pembroke Athleta | vs | Marsaxlokk |
| 29/10/2021 | 21:00 | Centenary Stadium | Marsaxlokk | vs | Mqabba |
| 30/10/2021 | 21:00 | Centenary Stadium | Rabat Ajax | vs | St. George’s |
| 30/10/2021 | 19:00 | Victor Tedesco Stadium | Pembroke Athleta | vs | Zejtun Corinthians |
| 31/10/2021 | 19:00 | Victor Tedesco Stadium | San Gwann | vs | Melita |
| 01/11/2021 | 21:00 | Centenary Stadium | Naxxar Lions | vs | Vittoriosa Stars |
| 19/11/2021 | 17:00 | Centenary Stadium | Mqabba | vs | Pembroke Athleta |
| 20/11/2021 | 14:00 | Centenary Stadium | St. George’s | vs | Marsaxlokk |
| 20/11/2021 | 14:00 | Victor Tedesco Stadium | Lija Athletic | vs | Rabat Ajax |
| 21/11/2021 | 15:00 | Centenary Stadium | Zejtun Corinthians | vs | Vittoriosa Stars |
| 21/11/2021 | 14:00 | Victor Tedesco Stadium | Melita | vs | Naxxar Lions |
| 27/11/2021 | 18:00 | Centenary Stadium | Pembroke Athleta | vs | St. George’s |
| 27/11/2021 | 18:00 | Victor Tedesco Stadium | Marsaxlokk | vs | Lija Athletic |
| 28/11/2021 | 19:00 | Centenary Stadium | Mqabba | vs | Zejtun Corinthians |
| 28/11/2021 | 18:00 | Victor Tedesco Stadium | Vittoriosa Stars | vs | Melita |
| 29/11/2021 | 21:00 | Centenary Stadium | Rabat Ajax | vs | San Gwann |
| 03/12/2021 | 17:00 | Centenary Stadium | Zejtun Corinthians | vs | Melita |
| 04/12/2021 | 14:00 | Centenary Stadium | St. George’s | vs | Mqabba |
| 04/12/2021 | 14:00 | Victor Tedesco Stadium | San Gwann | vs | Marsaxlokk |
| 05/12/2021 | 15:00 | Centenary Stadium | Naxxar Lions | vs | Rabat Ajax |
| 05/12/2021 | 14:00 | Victor Tedesco Stadium | Lija Athletic | vs | Pembroke Athleta |
| 11/12/2021 | 18:00 | Centenary Stadium | Marsaxlokk | vs | Naxxar Lions |
| 11/12/2021 | 18:00 | Victor Tedesco Stadium | Rabat Ajax | vs | Vittoriosa Stars |
| 12/12/2021 | 19:00 | Centenary Stadium | Pembroke Athleta | vs | San Gwann |
| 12/12/2021 | 18:00 | Victor Tedesco Stadium | St. George’s | vs | Zejtun Corinthians |
| 13/12/2021 | 18:00 | Centenary Stadium | Mqabba | vs | Lija Athletic |
| 17/12/2021 | 17:00 | Centenary Stadium | Naxxar Lions | vs | Pembroke Athleta |
| 18/12/2021 | 14:00 | Centenary Stadium | San Gwann | vs | Mqabba |
| 18/12/2021 | 14:00 | Victor Tedesco Stadium | Vittoriosa Stars | vs | Marsaxlokk |
| 19/12/2021 | 15:00 | Centenary Stadium | Melita | vs | Rabat Ajax |
| 19/12/2021 | 14:00 | Victor Tedesco Stadium | Lija Athletic | vs | St. George’s |
Group B
| 15/10/2021 | 17:00 | Centenary Stadium | Tarxien Rainbows | vs | St. Andrews |
| 16/10/2021 | 15:00 | Centenary Stadium | Qrendi | vs | Senglea Athletic |
| 16/10/2021 | 15:00 | Victor Tedesco Stadium | Swieqi United | vs | Zebbug Rangers |
| 17/10/2021 | 15:00 | Centenary Stadium | Mgarr United | vs | Marsa |
| 17/10/2021 | 15:00 | Victor Tedesco Stadium | Fgura United | vs | Luqa St. Andrew’s |
| 22/10/2021 | 21:00 | Centenary Stadium | Luqa St. Andrew’s | vs | Tarxien Rainbows |
| 23/10/2021 | 21:00 | Centenary Stadium | Marsa | vs | Qrendi |
| 23/10/2021 | 19:00 | Victor Tedesco Stadium | Senglea Athletic | vs | Zebbug Rangers |
| 24/10/2021 | 19:00 | Victor Tedesco Stadium | St. Andrews | vs | Swieqi United |
| 25/10/2021 | 21:00 | Victor Tedesco Stadium | Pieta’ Hotspurs | vs | Mgarr United |
| 29/10/2021 | 17:00 | Centenary Stadium | Swieqi United | vs | Luqa St. Andrew’s |
| 30/10/2021 | 13:00 | Centenary Stadium | Zebbug Rangers | vs | St. Andrews |
| 30/10/2021 | 15:00 | Victor Tedesco Stadium | Marsa | vs | Senglea Athletic |
| 31/10/2021 | 11:00 | Centenary Stadium | Qrendi | vs | Pieta’ Hotspurs |
| 31/10/2021 | 15:00 | Victor Tedesco Stadium | Mgarr United | vs | Fgura United |
| 19/11/2021 | 21:00 | Centenary Stadium | Fgura United | vs | Qrendi |
| 20/11/2021 | 18:00 | Centenary Stadium | Tarxien Rainbows | vs | Mgarr United |
| 20/11/2021 | 18:00 | Victor Tedesco Stadium | Pieta’ Hotspurs | vs | Marsa |
| 21/11/2021 | 19:00 | Centenary Stadium | Senglea Athletic | vs | St. Andrews |
| 21/11/2021 | 18:00 | Victor Tedesco Stadium | Luqa St. Andrew’s | vs | Zebbug Rangers |
| 27/11/2021 | 14:00 | Centenary Stadium | Marsa | vs | Fgura United |
| 27/11/2021 | 14:00 | Victor Tedesco Stadium | Mgarr United | vs | Swieqi United |
| 28/11/2021 | 15:00 | Centenary Stadium | Qrendi | vs | Tarxien Rainbows |
| 28/11/2021 | 14:00 | Victor Tedesco Stadium | St. Andrews | vs | Luqa St. Andrew’s |
| 29/11/2021 | 17:00 | Centenary Stadium | Pieta’ Hotspurs | vs | Senglea Athletic |
| 03/12/2021 | 21:00 | Centenary Stadium | Zebbug Rangers | vs | Mgarr United |
| 04/12/2021 | 18:00 | Centenary Stadium | Swieqi United | vs | Qrendi |
| 04/12/2021 | 18:00 | Victor Tedesco Stadium | Tarxien Rainbows | vs | Marsa |
| 05/12/2021 | 19:00 | Centenary Stadium | Senglea Athletic | vs | Luqa St. Andrew’s |
| 05/12/2021 | 18:00 | Victor Tedesco Stadium | Fgura United | vs | Pieta’ Hotspurs |
| 11/12/2021 | 14:00 | Centenary Stadium | Fgura United | vs | Senglea Athletic |
| 11/12/2021 | 14:00 | Victor Tedesco Stadium | Mgarr United | vs | St. Andrews |
| 12/12/2021 | 15:00 | Centenary Stadium | Marsa | vs | Swieqi United |
| 12/12/2021 | 14:00 | Victor Tedesco Stadium | Qrendi | vs | Zebbug Rangers |
| 13/12/2021 | 14:00 | Centenary Stadium | Pieta’ Hotspurs | vs | Tarxien Rainbows |
| 17/12/2021 | 21:00 | Centenary Stadium | Zebbug Rangers | vs | Marsa |
| 18/12/2021 | 18:00 | Centenary Stadium | Luqa St. Andrew’s | vs | Mgarr United |
| 18/12/2021 | 18:00 | Victor Tedesco Stadium | St. Andrews | vs | Qrendi |
| 19/12/2021 | 19:00 | Centenary Stadium | Swieqi United | vs | Pieta’ Hotspurs |
| 19/12/2021 | 18:00 | Victor Tedesco Stadium | Tarxien Rainbows | vs | Fgura United |
