Qormi had already defeated Tarxien twice this season – 6-2 and 3-0 – and therefore seek a third win over Clive Mizzi’s side.
In the third round, Qormi beat SK Victoria Wanderers 1-0 after extra-time. while Tarxien Rainbows defeated Second Division side Mellieha 1-0.
The game kicks-off at 20:15.
Meanwhile in the first match, First Division side St. Andrews take on BOV Premier League leaders Birkirkara, kick-off at 18:00.
The Stripes lead the Premier League table with a comfortable six-point lead and are coming from an impressive record of twelve successive wins. St. Andrews, on the other hand, are currently ninth in the BOV First Division and after a rather positive start, they failed to win any of the last eight matches.
In the previous rounds, St. Andrews defeated Third Division side Mgarr United 3-0 and Second Division side San Gwann 2-1. Birkirkara, on the other hand, beat another Premier League side Vittoriosa Stars 4-1.
The last five fourth round matches will be played on Wednesday as follows:
18:00 Hibernians vs Pietà H. (Centenary Stadium)
20:15 Floriana vs Naxxar L. (Centenary Stadium)
18:00 Kercem A. vs Rabat A. (Kercem Ajax Ground)
18:00 Sliema W. vs Balzan (Victor Tedesco Stadium)
20:15 Valletta vs Mosta (Victor Tedesco Stadium)