Patrick Jean Texeira Maia put Santa Lucia ahead ten minutes in the second half but Wilmsen Moacir da Rosa equalised on the 74th minute.
Zejtun Corinthians continue to disappoint after losing 0-1 to Gudja United. Adolphus Nagbe Marshall scored the all-important goal on the 55th minute.
In another match, Marsa and Zebbug Rangers shared the spoils in a goalless draw.
Santa Lucia lead the way with 18 points, followed by Sirens on 15, Zebbug and Gudja 13, Vittoriosa and Mqabba 12, Qrendi and Pembroke 11, Lija, Swieqi and Naxxar 10, Zejtun 7, Marsa 5 and San Gwann 0.