The Malta Football Association released the fixtures for match day 4 to match day 11 of the BOV Challenge League 2021/22.
Group A
| Friday 07/Jan/2022 | 21:00 | Centenary Stadium | Pembroke Athleta | vs | Vittoriosa Stars |
| Saturday 08/Jan/2022 | 18:00 | Centenary Stadium | Marsaxlokk | vs | Melita |
| Saturday 08/Jan/2022 | 18:00 | Victor Tedesco Stadium | St. George’s | vs | San Gwann |
| Sunday 09/Jan/2022 | 19:00 | Centenary Stadium | Lija Athletic | vs | Zejtun Corinthians |
| Sunday 09/Jan/2022 | 18:00 | Victor Tedesco Stadium | Mqabba | vs | Naxxar Lions |
| Friday 14/Jan/2022 | 17:00 | Centenary Stadium | Melita | vs | Pembroke Athleta |
| Saturday 15/Jan/2022 | 14:00 | Centenary Stadium | Vittoriosa Stars | vs | Mqabba |
| Saturday 15/Jan/2022 | 14:00 | Victor Tedesco Stadium | Naxxar Lions | vs | St. George’s |
| Sunday 16/Jan/2022 | 15:00 | Centenary Stadium | San Gwann | vs | Lija Athletic |
| Sunday 16/Jan/2022 | 14:00 | Victor Tedesco Stadium | Zejtun Corinthians | vs | Rabat Ajax |
| Friday 28/Jan/2022 | 21:00 | Centenary Stadium | Lija Athletic | vs | Naxxar Lions |
| Saturday 29/Jan/2022 | 20:00 | Centenary Stadium | San Gwann | vs | Zejtun Corinthians |
| Saturday 29/Jan/2022 | 18:00 | Victor Tedesco Stadium | Mqabba | vs | Melita |
| Sunday 30/Jan/2022 | 19:00 | Centenary Stadium | St. George’s | vs | Vittoriosa Stars |
| Sunday 30/Jan/2022 | 18:00 | Victor Tedesco Stadium | Rabat Ajax | vs | Marsaxlokk |
| Friday 04/Feb/2022 | 17:00 | Centenary Stadium | Zejtun Corinthians | vs | Marsaxlokk |
| Saturday 05/Feb/2022 | 14:00 | Centenary Stadium | Melita | vs | St. George’s |
| Saturday 05/Feb/2022 | 14:00 | Victor Tedesco Stadium | Vittoriosa Stars | vs | Lija Athletic |
| Sunday 06/Feb/2022 | 15:00 | Centenary Stadium | Naxxar Lions | vs | San Gwann |
| Sunday 06/Feb/2022 | 14:00 | Victor Tedesco Stadium | Pembroke Athleta | vs | Rabat Ajax |
| Friday 11/Feb/2022 | 21:00 | Centenary Stadium | San Gwann | vs | Vittoriosa Stars |
| Saturday 12/Feb/2022 | 18:00 | Centenary Stadium | Marsaxlokk | vs | Pembroke Athleta |
| Saturday 12/Feb/2022 | 18:00 | Victor Tedesco Stadium | Rabat Ajax | vs | Mqabba |
| Sunday 13/Feb/2022 | 19:00 | Centenary Stadium | Lija Athletic | vs | Melita |
| Sunday 13/Feb/2022 | 18:00 | Victor Tedesco Stadium | Naxxar Lions | vs | Zejtun Corinthians |
| Friday 18/Feb/2022 | 17:00 | Centenary Stadium | Melita | vs | San Gwann |
| Saturday 19/Feb/2022 | 14:00 | Victor Tedesco Stadium | Mqabba | vs | Marsaxlokk |
| Sunday 20/Feb/2022 | 16:00 | Centenary Stadium | Vittoriosa Stars | vs | Naxxar Lions |
| Sunday 20/Feb/2022 | 14:00 | Victor Tedesco Stadium | Zejtun Corinthians | vs | Pembroke Athleta |
| Monday 21/Feb/2022 | 17:00 | Centenary Stadium | St. George’s | vs | Rabat Ajax |
| Friday 25/Feb/2022 | 21:00 | Centenary Stadium | Vittoriosa Stars | vs | Zejtun Corinthians |
| Saturday 26/Feb/2022 | 18:00 | Centenary Stadium | Naxxar Lions | vs | Melita |
| Saturday 26/Feb/2022 | 18:00 | Victor Tedesco Stadium | Marsaxlokk | vs | St. George’s |
| Sunday 27/Feb/2022 | 19:00 | Centenary Stadium | Rabat Ajax | vs | Lija Athletic |
| Sunday 27/Feb/2022 | 18:00 | Victor Tedesco Stadium | Pembroke Athleta | vs | Mqabba |
| Friday 04/Mar/2022 | 17:00 | Centenary Stadium | Zejtun Corinthians | vs | Mqabba |
| Saturday 05/Mar/2022 | 14:00 | Centenary Stadium | Melita | vs | Vittoriosa Stars |
| Saturday 05/Mar/2022 | 14:00 | Victor Tedesco Stadium | St. George’s | vs | Pembroke Athleta |
| Sunday 06/Mar/2022 | 15:00 | Centenary Stadium | Lija Athletic | vs | Marsaxlokk |
| Sunday 06/Mar/2022 | 14:00 | Victor Tedesco Stadium | San Gwann | vs | Rabat Ajax |
| Friday 11/Mar/2022 | 21:00 | Centenary Stadium | Marsaxlokk | vs | San Gwann |
| Saturday 12/Mar/2022 | 18:00 | Centenary Stadium | Mqabba | vs | St. George’s |
| Saturday 12/Mar/2022 | 18:00 | Victor Tedesco Stadium | Melita | vs | Zejtun Corinthians |
| Sunday 13/Mar/2022 | 19:00 | Centenary Stadium | Rabat Ajax | vs | Naxxar Lions |
| Sunday 13/Mar/2022 | 18:00 | Victor Tedesco Stadium | Pembroke Athleta | vs | Lija Athletic |
Group B
| Friday 07/Jan/2022 | 17:00 | Centenary Stadium | Pieta’ Hotspurs | vs | Zebbug Rangers |
| Saturday 08/Jan/2022 | 14:00 | Centenary Stadium | Fgura United | vs | Swieqi United |
| Saturday 08/Jan/2022 | 14:00 | Victor Tedesco Stadium | Marsa | vs | St. Andrews |
| Sunday 09/Jan/2022 | 15:00 | Centenary Stadium | Tarxien Rainbows | vs | Senglea Athletic |
| Sunday 09/Jan/2022 | 14:00 | Victor Tedesco Stadium | Qrendi | vs | Luqa St. Andrew’s |
| Friday 14/Jan/2022 | 21:00 | Centenary Stadium | Luqa St. Andrew’s | vs | Marsa |
| Saturday 15/Jan/2022 | 18:00 | Centenary Stadium | Senglea Athletic | vs | Mgarr United |
| Saturday 15/Jan/2022 | 18:00 | Victor Tedesco Stadium | Swieqi United | vs | Tarxien Rainbows |
| Sunday 16/Jan/2022 | 19:00 | Centenary Stadium | Zebbug Rangers | vs | Fgura United |
| Sunday 16/Jan/2022 | 18:00 | Victor Tedesco Stadium | St. Andrews | vs | Pieta’ Hotspurs |
| Friday 28/Jan/2022 | 17:00 | Centenary Stadium | Mgarr United | vs | Qrendi |
| Saturday 29/Jan/2022 | 12:00 | Centenary Stadium | Fgura United | vs | St. Andrews |
| Saturday 29/Jan/2022 | 14:00 | Victor Tedesco Stadium | Tarxien Rainbows | vs | Zebbug Rangers |
| Sunday 30/Jan/2022 | 15:00 | Centenary Stadium | Pieta’ Hotspurs | vs | Luqa St. Andrew’s |
| Sunday 30/Jan/2022 | 14:00 | Victor Tedesco Stadium | Swieqi United | vs | Senglea Athletic |
| Friday 04/Feb/2022 | 21:00 | Centenary Stadium | Zebbug Rangers | vs | Swieqi United |
| Saturday 05/Feb/2022 | 18:00 | Centenary Stadium | Luqa St. Andrew’s | vs | Fgura United |
| Saturday 05/Feb/2022 | 18:00 | Victor Tedesco Stadium | Senglea Athletic | vs | Qrendi |
| Sunday 06/Feb/2022 | 19:00 | Centenary Stadium | Marsa | vs | Mgarr United |
| Sunday 06/Feb/2022 | 18:00 | Victor Tedesco Stadium | St. Andrews | vs | Tarxien Rainbows |
| Friday 11/Feb/2022 | 17:00 | Centenary Stadium | Zebbug Rangers | vs | Senglea Athletic |
| Saturday 12/Feb/2022 | 14:00 | Centenary Stadium | Swieqi United | vs | St. Andrews |
| Saturday 12/Feb/2022 | 14:00 | Victor Tedesco Stadium | Mgarr United | vs | Pieta’ Hotspurs |
| Sunday 13/Feb/2022 | 15:00 | Centenary Stadium | Tarxien Rainbows | vs | Luqa St. Andrew’s |
| Sunday 13/Feb/2022 | 14:00 | Victor Tedesco Stadium | Qrendi | vs | Marsa |
| Friday 18/Feb/2022 | 21:00 | Centenary Stadium | Luqa St. Andrew’s | vs | Swieqi United |
| Saturday 19/Feb/2022 | 18:00 | Victor Tedesco Stadium | Senglea Athletic | vs | Marsa |
| Sunday 20/Feb/2022 | 20:00 | Centenary Stadium | Pieta’ Hotspurs | vs | Qrendi |
| Sunday 20/Feb/2022 | 18:00 | Victor Tedesco Stadium | Fgura United | vs | Mgarr United |
| Monday 21/Feb/2022 | 21:00 | Centenary Stadium | St. Andrews | vs | Zebbug Rangers |
| Friday 25/Feb/2022 | 17:00 | Centenary Stadium | Marsa | vs | Pieta’ Hotspurs |
| Saturday 26/Feb/2022 | 14:00 | Centenary Stadium | St. Andrews | vs | Senglea Athletic |
| Saturday 26/Feb/2022 | 14:00 | Victor Tedesco Stadium | Zebbug Rangers | vs | Luqa St. Andrew’s |
| Sunday 27/Feb/2022 | 15:00 | Centenary Stadium | Qrendi | vs | Fgura United |
| Sunday 27/Feb/2022 | 14:00 | Victor Tedesco Stadium | Mgarr United | vs | Tarxien Rainbows |
| Friday 04/Mar/2022 | 21:00 | Centenary Stadium | Swieqi United | vs | Mgarr United |
| Saturday 05/Mar/2022 | 18:00 | Centenary Stadium | Luqa St. Andrew’s | vs | St. Andrews |
| Saturday 05/Mar/2022 | 18:00 | Victor Tedesco Stadium | Tarxien Rainbows | vs | Qrendi |
| Sunday 06/Mar/2022 | 19:00 | Centenary Stadium | Fgura United | vs | Marsa |
| Sunday 06/Mar/2022 | 18:00 | Victor Tedesco Stadium | Senglea Athletic | vs | Pieta’ Hotspurs |
| Friday 11/Mar/2022 | 17:00 | Centenary Stadium | Qrendi | vs | Swieqi United |
| Saturday 12/Mar/2022 | 14:00 | Centenary Stadium | Marsa | vs | Tarxien Rainbows |
| Saturday 12/Mar/2022 | 14:00 | Victor Tedesco Stadium | Pieta’ Hotspurs | vs | Fgura United |
| Sunday 13/Mar/2022 | 15:00 | Centenary Stadium | Mgarr United | vs | Zebbug Rangers |
| Sunday 13/Mar/2022 | 14:00 | Victor Tedesco Stadium | Luqa St. Andrew’s | vs | Senglea Athletic |
