The Malta Football Association released the fixtures for the Izibet FA Trophy Round of 32.
Matches will be played between Tuesday 8 and Thursday 10 February and between Tuesday 15 and Wednesday 16 February.
| Tuesday 08/Feb/2022 | 20:30 | Centenary Stadium | Mosta | vs | Luqa St. Andrew’s |
| Tuesday 08/Feb/2022 | 18:30 | Tony Bezzina Stadium | Hibernians | vs | Nadur Youngsters |
| Tuesday 08/Feb/2022 | 20:30 | Victor Tedesco Stadium | Melita | vs | St. George’s |
| Wednesday 09/Feb/2022 | 17:00 | Centenary Stadium | Marsaskala | vs | Valletta |
| Wednesday 09/Feb/2022 | 21:00 | Centenary Stadium | Gudja United | vs | Swieqi United |
| Wednesday 09/Feb/2022 | 18:30 | National Stadium | Floriana | vs | Ghajnsielem |
| Wednesday 09/Feb/2022 | 19:00 | Tony Bezzina Stadium | Balzan | vs | Pieta’ Hotspurs |
| Wednesday 09/Feb/2022 | 20:30 | Victor Tedesco Stadium | Marsa | vs | Tarxien Rainbows |
| Thursday 10/Feb/2022 | 11:00 | Centenary Stadium | Hamrun Spartans | vs | Naxxar Lions |
| Thursday 10/Feb/2022 | 15:00 | Centenary Stadium | Sliema Wanderers | vs | Vittoriosa Stars |
| Thursday 10/Feb/2022 | 19:00 | Centenary Stadium | Birkirkara | vs | Fgura United |
| Thursday 10/Feb/2022 | 19:00 | Tony Bezzina Stadium | Sta. Lucia | vs | Sirens |
| Thursday 10/Feb/2022 | 16:00 | Victor Tedesco Stadium | Zejtun Corinthians | vs | Xewkija Tigers |
| Tuesday 15/Feb/2022 | 20:30 | Victor Tedesco Stadium | Pembroke Athleta | vs | Marsaxlokk |
| Wednesday 16/Feb/2022 | 20:30 | Centenary Stadium | Gzira United | vs | Zabbar St. Patrick |
| Wednesday 16/Feb/2022 | 20:30 | Victor Tedesco Stadium | Zebbug Rangers | vs | St. Andrews |