The Malta Football Association released the fixtures for the Round of 16 of the Izibet FA Trophy.
Twelve Premier League clubs are joined by Challenge League sides San Gwann and Swieqi United and Gozitan sides Kercem Ajax and Qala Saints in this round.
Matches will be played between February 7 and 9 as follows:
| Tue 7-Feb-2023 | Mosta FC vs Swieqi United FC | 18:00 | Centenary Stadium |
| Wed 8-Feb-2023 | Balzan FC vs Birkirkara FC | 17:00 | National Stadium |
| Wed 8-Feb-2023 | Hibernians FC vs Kercem Ajax | 19:00 | Tony Bezzina Stadium |
| Wed 8-Feb-2023 | Gudja United FC vs Sirens FC | 19:30 | Centenary Stadium |
| Wed 8-Feb-2023 | Valletta FC vs Hamrun Spartans FC | 19:30 | National Stadium |
| Wed 8-Feb-2023 | Pieta’ Hotspurs FC vs San Gwann FC | 19:30 | Victor Tedesco Stadium |
| Thu 9-Feb-2023 | Santa Lucia FC vs Marsaxlokk FC | 19:00 | Tony Bezzina Stadium |
| Thu 9-Feb-2023 | Gzira United FC vs Qala Saints | 20:00 | Centenary Stadium |
The quarter-finals are scheduled for February 24-26, the semi-finals for April 25-26 and the final for April 30.