| Season | Round | 1st Leg | 2nd Leg | Aggregate | |
| 1961/62 | Q | Floriana vs Ujpest Dosza (HUN) | 2-5 | 2-10 | (4-15) |
| 1962/63 | R1 | Atletico Madrid (SPA) vs Hibernians | 4-0 | 1-0 | (5-0) |
| 1963/64 | R1 | Sliema Wanderers vs Borough United (WAL) | 0-0 | 0-2 | (0-2) |
| 1964/65 | R1 | Valletta vs Real Saragoza (SPA) | 0-3 | 1-5 | (1-8) |
| 1965/66 | R1 | Floriana vs Borussia Dortmund (GER) | 1-5 | 0-8 | (1-13) |
| 1966/67 | R1 | Floriana vs Sparta Rotterdam (NED) | 1-1 | 0-6 | (1-7) |
| 1967/68 | R1 | Floriana vs NAC Breda (NED) | 1-2 | 0-1 | (1-3) |
| 1968/69 | R1 | Rumelange (LUX) vs SLIEMA WANDERERS | 2-1 | 0-1 | (2-2)* |
| R2 | Randers Freja (DEN) vs Sliema Wanderers | 6-0 | 2-0 | (8-0) | |
| 1969/70 | R1 | Norrkoping (SWE) vs Sliema Wanderers | 5-1 | 0-1 | (5-2) |
| 1970/71 | R1 | Hibernians vs Real Madrid (SPA) | 0-0 | 0-5 | (0-5) |
| 1971/72 | Q | HIBERNIANS vs Fram Reykjavik (ICE) | 0-2 | 3-0 | (3-2)** |
| R1 | Hibernians vs Steaua Bucharest (ROM) | 0-0 | 0-1 | (0-1) | |
| 1972/73 | R1 | Floriana vs Ferencvaros (HUN) | 1-0 | 0-6 | (1-6) |
| 1973/74 | R1 | Gzira United vs Brann Bergen (NOR) | 0-2 | 0-7 | (0-9) |
| 1974/75 | R1 | Sliema Wanderers vs Reipas Lahti (FIN) | 2-0 | 1-4 | (3-4) |
| 1975/76 | R1 | Haladas Szombathely (HUN) vs Valletta | 7-0 | 1-1 | (8-1) |
| 1976/77 | R1 | Floriana vs Slask Wroclaw (POL) | 1-4 | 0-2 | (1-6) |
| 1977/78 | R1 | Valletta vs Dinamo Moscow (USR) | 0-2 | 0-5 | (0-7) |
| 1978/79 | R1 | Floriana vs Inter (ITA) | 1-3 | 0-5 | (1-8) |
| 1979/80 | R1 | Sliema Wanderers vs Boavista (POR) | 2-1 | 0-8 | (2-9) |
| 1980/81 | R1 | Hibernians vs Waterford (EIR) | 1-0 | 0-4 | (1-4) |
| 1981/82 | R1 | Floriana vs Standard Liege (BEL) | 1-3 | 0-9 | (1-12) |
| 1982/83 | R1 | Swansea City (WAL) vs Sliema Wanderers | 12-0 | 5-0 | (17-0) |
| 1983-84 | R1 | Valletta vs Rangers Glasgow (SCO) | 0-8 | 0-10 | (0-18) |
| 1984/85 | R1 | Ballymena (NIR) vs HAMRUN SPARTANS | 0-1 | 1-2 | (1-3) |
| R2 | Dinamo Moscow (USR) vs Hamrun Spartans | 5-0 | 1-0 | (6-0) | |
| 1985/86 | R1 | Zurrieq vs Bayer Uerdingen (GER) | 0-3 | 0-9 | (0-12) |
| 1986/87 | R1 | Zurrieq vs Wrexham (WAL) | 0-3 | 0-4 | (0-7) |
| 1987/88 | R1 | Vlanzia Shkoder (ALB) vs Sliema Wanderers | 2-0 | 4-0 | (6-0) |
| 1988/89 | R1 | Floriana vs Dundee United (SCO) | 0-0 | 0-1 | (0-1) |
| 1989/90 | R1 | Real Valladolid (SPA) vs Hamrun Spartans | 5-0 | 1-0 | (6-0) |
| 1990/91 | R1 | Sliema Wanderers vs Dukla Prague (CZE) | 1-2 | 0-2 | (1-4) |
| 1991/92 | R1 | Valletta vs Porto (POR) | 0-3 | 0-1 | (0-4) |
| 1992/93 | Q | Maribor Branik (SLV) vs Hamrun Spartans | 4-0 | 1-2 | (5-2) |
| 1993/94 | Q | Sliema Wanderers vs Degersfors (SWE) | 1-3 | 0-3 | (1-6) |
| 1994/95 | Q | Floriana vs Sligo Rovers (EIR) | 2-2 | 0-1 | (2-3) |
| 1995/96 | Q | Valletta vs Inter Bratislava (SVK) | 0-0 | 2-5 | (2-5) |
| 1996/97 | Q | Valletta vs Gloria Bistrita (ROM) | 1-2 | 1-2 | (2-4) |
| 1997/98 | Q | Hibernians vs IB Vestmannaeyjar (ICE) | 0-1 | 0-3 | (0-4) |
| 1998/99 | Q | KS Amica Wronki (POL) vs Hibernians | 4-0 | 1-0 | (5-0) |
* Sliema Wanderers go through on the away goal.
** Both matches were played in Malta.
Notes:-
- Names of local clubs in uppercase indicate that the club moved to the next round.