Newly-promoted duo Melita and Rabat Ajax will be all out to claim the three points on Saturday as the two teams cross swords in one of the two matches in programme at the National Stadium on Saturday.
The Amateurs lost 0-4 to Birkirkara last week while the Magpies suffered a narrow defeat to Qormi.
Coaches Martin Gregory and Silvio Vella are not expected to make numerous changes to their line-ups.
Meanwhile in the second game, Qormi take on Hibernians.
Both sides registered wins in their first outing as Qormi defeated Rabat and Hiberniana survived a good comeback by Mosta beating them 3-2.
The biggest concern for Hibernians is the absence of a number of players. Clayton Failla is suspended, Jean Paul Farrugia is ruled out injured while the presence of Edward Herrera and Jason Vandelannoite is in doubt after both missed the game against Mosta.