The runner-up spot could be at stake as Valletta take on Birkirkara in one of the four matches from the BOV Premier League in programme on Saturday.
Tarxien vs Qormi and Pietà vs Zebbug may give an indication with regards to which way the relegation battle is going while Sliema face Mosta in a clash between two teams in mid-table.
Sliema Wanderers vs Mosta, kick-off 17:00 at Victor Tedesco Stadium
Lying sixth and seventh respectively, Sliema and Mosta lie in a rather comfortable mid-table position. The Wanderers won just one of the last seven matches but held Valletta in a 3-3 draw last week after losing by the odd goal in five to Hibernians the previous week. Mosta, on the other hand, won just two out of the last twelve matches, losing 1-2 to Tarxien last week.
Djumo Bocar is ruled out for Sliema as he serves a one-match ban.
In the previous rounds, Sliema beat Mosta 4-1 and 2-1.
Tarxien Rainbows vs Qormi, kick-off 19:15 at Victor Tedesco Stadium
Two wins in their last two matches against Naxxar and Mosta enabled Tarxien to bounce from twelfth to ninth and another win in this direct clash on Saturday would put them closer to securing their Premier League status.
Qormi lie two points behind Tarxien, two ahead of Pietà and three ahead of Zebbug and need to return to winning ways in order to maintain alive hopes of avoiding relegation and even the relegation play-off. They won just one of the last twenty-one matches, earning three points in three draws from the last five matches. Last week they lost 1-5 to Balzan.
For Tarxien, Alex Cini is suspended but Mouhamed Soly returns after serving a three-match ban.
Qormi beat Tarxien 1-0 in the first round but the second round clash ended in 2-1 win for the Rainbows.
Pietà Hotspurs vs Zebbug Rangers, kick-off 17:00 at National Stadium
A win for either side in this direct clash between the two bottom teams could restore hopes of avoiding a quick return to Division 1. The Hotspurs have gone eight games without a win but are coming from a goalless draw with Naxxar. The Rangers, on the other hand, lost the last seven matches, losing 1-3 to Birkirkara last week.
Christian Grech is ruled out for the Hotspurs as he serves a one-match ban.
Pietà defeated Zebbug 1-0 while Zebbug won 2-1 in the second round.
Valletta vs Birkirkara, kick-off 19:00 at National Stadium
With the league title going to Paola, third-placed Valletta and second-placed Birkirkara have definitely shifted their focus on the FA Trophy but this clash could determine the runner-up spot. Birkirkara are unbeaten in eighteen matches while Valletta were held in a 3-3 draw by Sliema after claiming maximum points from the previous six matches.
Birkirkara defeated Valletta 2-0 in the first round with the second round clash ending in a 1-1 draw.