Floriana will be aiming for maximum points on Friday as they take on Sirens at the National Stadium, kick-off at 19:00.
The Greens, who share the top spot with rivals Valletta, returned to winning ways two weeks ago as they beat Tarxien 4-0. They went on to defeat Birkirkara on penalties in the FA Trophy quarter-finals.
Sirens, on the other hand, won three out of their last five matches and are currently third on 35 points, three behind the two joint-leaders.
In the first round, Floriana defeated Sirens 4-1.