The Malta Football Association released the revised fixtures for match-days 12 to 14 of the BOV Challenge League.
| Monday 17/Jan/2022 | 17:00 | Centenary Stadium | Fgura United | vs | Swieqi United | B |
| Monday 17/Jan/2022 | 21:00 | Centenary Stadium | Pieta’ Hotspurs | vs | Zebbug Rangers | B |
| Monday 17/Jan/2022 | 17:00 | Victor Tedesco Stadium | Marsa | vs | St. Andrews | B |
| Monday 17/Jan/2022 | 21:00 | Victor Tedesco Stadium | St. George’s | vs | San Gwann | A |
| Tuesday 18/Jan/2022 | 21:00 | Centenary Stadium | Mqabba | vs | Naxxar Lions | A |
| Tuesday 18/Jan/2022 | 21:00 | Victor Tedesco Stadium | Pembroke Athleta | vs | Vittoriosa Stars | A |
| Wednesday 19/Jan/2022 | 21:00 | Victor Tedesco Stadium | Lija Athletic | vs | Zejtun Corinthians | A |
| Thursday 20/Jan/2022 | 17:00 | Centenary Stadium | Marsaxlokk | vs | Melita | A |
| Thursday 20/Jan/2022 | 21:00 | Centenary Stadium | Tarxien Rainbows | vs | Senglea Athletic | B |
| Thursday 20/Jan/2022 | 21:00 | Victor Tedesco Stadium | Qrendi | vs | Luqa St. Andrew’s | B |
| Friday 21/Jan/2022 | 17:00 | Centenary Stadium | Zebbug Rangers | vs | Fgura United | B |
| Friday 21/Jan/2022 | 21:00 | Centenary Stadium | Vittoriosa Stars | vs | Mqabba | A |
| Saturday 22/Jan/2022 | 12:00 | Centenary Stadium | San Gwann | vs | Lija Athletic | A |
| Saturday 22/Jan/2022 | 20:00 | Centenary Stadium | Zejtun Corinthians | vs | Rabat Ajax | A |
| Saturday 22/Jan/2022 | 14:00 | Victor Tedesco Stadium | Naxxar Lions | vs | St. George’s | A |
| Saturday 22/Jan/2022 | 18:00 | Victor Tedesco Stadium | St. Andrews | vs | Pieta’ Hotspurs | B |
| Sunday 23/Jan/2022 | 15:00 | Centenary Stadium | Luqa St. Andrew’s | vs | Marsa | B |
| Sunday 23/Jan/2022 | 19:00 | Centenary Stadium | Senglea Athletic | vs | Mgarr United | B |
| Sunday 23/Jan/2022 | 14:00 | Victor Tedesco Stadium | Swieqi United | vs | Tarxien Rainbows | B |
| Sunday 23/Jan/2022 | 18:00 | Victor Tedesco Stadium | Melita | vs | Pembroke Athleta | A |
| Friday 28/Jan/2022 | 17:00 | Centenary Stadium | Mgarr United | vs | Qrendi | B |
| Friday 28/Jan/2022 | 21:00 | Centenary Stadium | Lija Athletic | vs | Naxxar Lions | A |
| Saturday 29/Jan/2022 | 14:00 | Centenary Stadium | San Gwann | vs | Zejtun Corinthians | A |
| Saturday 29/Jan/2022 | 18:00 | Centenary Stadium | Fgura United | vs | St. Andrews | B |
| Saturday 29/Jan/2022 | 14:00 | Victor Tedesco Stadium | Tarxien Rainbows | vs | Zebbug Rangers | B |
| Saturday 29/Jan/2022 | 18:00 | Victor Tedesco Stadium | Mqabba | vs | Melita | A |
| Sunday 30/Jan/2022 | 15:00 | Centenary Stadium | St. George’s | vs | Vittoriosa Stars | A |
| Sunday 30/Jan/2022 | 19:00 | Centenary Stadium | Pieta’ Hotspurs | vs | Luqa St. Andrew’s | B |
| Sunday 30/Jan/2022 | 14:00 | Victor Tedesco Stadium | Swieqi United | vs | Senglea Athletic | B |
| Sunday 30/Jan/2022 | 18:00 | Victor Tedesco Stadium | Rabat Ajax | vs | Marsaxlokk | A |