The Malta Football Association announced changes in fixtures from the BOV Challenge League.
The following matches will be played as follows:
| Date | Time | Venue | Home | vs | Away |
| Friday 03-Dec-2021 | 17:00 | Centenary Stadium | Naxxar Lions | vs | Rabat Ajax |
| Friday 03-Dec-2021 | 21:00 | Centenary Stadium | Swieqi United | vs | Qrendi |
| Saturday 04-Dec-2021 | 18:00 | Centenary Stadium | Zebbug Rangers | vs | Mgarr United |
| Sunday 05-Dec-2021 | 15:00 | Centenary Stadium | Zejtun Corinthians | vs | Melita |