The Malta Football Association announced that due to the visit to Malta by Pope Francis on April 2 and 3, fixtures from the BOV Challenge League had to be rescheduled due to security, logistical and human resources requirements.
The only two matches which were not affected were Friday’s games at the Centenary Stadium which will be played as scheduled: San Gwann vs Pembroke Athleta at 17:00 and Swieqi United vs Marsa at 20:15.
The other fixtures will be as follows:
| Friday 01/Apr/2022 | 20:30 | Victor Tedesco Stadium | Zejtun Corinthians | vs | St. George’s |
| Sunday 03/Apr/2022 | 17:00 | Centenary Stadium | Naxxar Lions | vs | Marsaxlokk |
| Saturday 02/Apr/2022 | 17:00 | Victor Tedesco Stadium | Lija Athletic | vs | Mqabba |
| Saturday 02/Apr/2022 | 17:00 | Centenary Stadium | Zebbug Rangers | vs | Qrendi |
| Sunday 03/Apr/2022 | 17:00 | Victor Tedesco Stadium | St. Andrews | vs | Mgarr United |
| Monday 04/Apr/2022 | 17:00 | Centenary Stadium | Vittoriosa Stars | vs | Rabat Ajax |
| Monday 04/Apr/2022 | 20:15 | Centenary Stadium | Senglea Athletic | vs | Fgura United |
| Monday 04/Apr/2022 | 20:30 | Victor Tedesco Stadium | Tarxien Rainbows | vs | Pieta’ Hotspurs |
updated 24/03/2022: Naxxar vs Marsaxlokk and Zebbug vs Qrendi were switched and will be played on Sunday 3 and Saturday 2 respectively